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Antigenic variation in current human type A influenzaviruses: Antigenic characteristics of the variants and their geographic distribution

Identifieur interne : 000203 ( 1968/Analysis ); précédent : 000202; suivant : 000204

Antigenic variation in current human type A influenzaviruses: Antigenic characteristics of the variants and their geographic distribution

Auteurs : G. C. Schild ; M. Henry-Aymard ; M. S. Pereira ; P. Chakraverty ; W. Dowdle ; M. Coleman ; W. K. Chang

Source :

RBID : PMC:2481068

Abstract

Outbreaks of influenza due to the virus A/Hong Kong/1/68 (H3N2) began in 1968 and are still occurring. The haemagglutinin of this virus is different from that of the A/Singapore/1/57 virus (the “Asian” strain) but the neuraminidase antigens are the same. Between 1968 and 1971 only minor antigenic “drift” in the haemagglutinin was noted, but in recent months 2 isolates have been identified in which considerable “drift” has occurred in the haemagglutinin and in the neuraminidase antigens. One, A/Hong Kong/5/72 (H3N2), was first detected in outbreaks in Hong Kong between November 1971 and January 1972 and was predominant there and in Korea but did not become widely disseminated. The second strain, A/England/42/72 (H3N2), has been isolated in winter outbreaks in the southern hemisphere and now appears to be the predominant strain in the northern hemisphere. The characteristics of the strains are described.

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Url:
PubMed: 4200741
PubMed Central: 2481068


Affiliations:


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PMC:2481068

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<p>Outbreaks of influenza due to the virus A/Hong Kong/1/68 (H3N2) began in 1968 and are still occurring. The haemagglutinin of this virus is different from that of the A/Singapore/1/57 virus (the “Asian” strain) but the neuraminidase antigens are the same. Between 1968 and 1971 only minor antigenic “drift” in the haemagglutinin was noted, but in recent months 2 isolates have been identified in which considerable “drift” has occurred in the haemagglutinin and in the neuraminidase antigens. One, A/Hong Kong/5/72 (H3N2), was first detected in outbreaks in Hong Kong between November 1971 and January 1972 and was predominant there and in Korea but did not become widely disseminated. The second strain, A/England/42/72 (H3N2), has been isolated in winter outbreaks in the southern hemisphere and now appears to be the predominant strain in the northern hemisphere. The characteristics of the strains are described.</p>
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   |texte=   Antigenic variation in current human type A influenzaviruses: Antigenic characteristics of the variants and their geographic distribution
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